Researchers create gel that regrows tooth enamel (2015)
dentistryiq.com
dentistryiq.com
2014 - "No more fillings as dentists reveal new tooth decay treatment" https://www.theguardian.com/society/2014/jun/16/fillings-den...
2011 - "An end to the dentist's drill: New painless cavity filler could be on the market in two years" http://www.dailymail.co.uk/health/article-2077816/Scared-den...
2004 - "No drilling, no filling in painless dentistry" http://www.telegraph.co.uk/news/uknews/1477044/No-drilling-n...
1998 - "Dental lasers – are they the safest way to fill your cavity?" http://judyforeman.com/columns/dental-lasers-are-they-safest...
Seriously though, it really is just announcements that state something is available now that people outside of a particular profession should care about.
The easy money is in the hyping of potential cures, and it's easy to see why. Even in this HN thread where you'd expect the level of scientific understanding and healthy skepticism to be fairly high, you see a lot of "Wow, it's about time" type responses. Now imagine the response of the politician controlling grant money who has no background in science.
We have an unsustainable systemic problem arising from the need to convince governments filled with anti-science politicians to fund expensive science. The institutions therefore feel the need to oversell every tiny paper so voters and politicians believe we're getting somewhere fast and won't kill funding, but the pace of real science is always fits and starts. You see a lot of people who have somehow figured out how to search the literature and cherry pick a paper they don't like as evidence of wasteful spending, and the system believes (falsely in my view) that overselling and oversimplifying results in a language that voters and politicians can understand.
Edit: I should have also said that the other big motivating factor for institutional press offices is to market the institution to other potential donors.
Novamin is a bioglass that is fortified in Sensodyne, which coats the enamel (a fluoride rival, but better), and was sold to GSK. After that, it suddenly disappeared from shelves in the US.
You can still buy it online (it ships mainly from Europe), but not in the stores.
It's all one big racket.
I understand the need for IP to make the investment worthwhile. But when buying it out like this, it should be a use it or lose it situation with the patent. Depriving people of a better solution to make a profit ain't right.
To understand you correctly, do you think the fluoride is a bad thing? IIRC fluoridated water is amongst the best bang for the buck you can do for healthy teeth, with no downside that I'm aware of (?)
https://www.amazon.com/Sensodyne-Repair-Protect-Whitening-To...
In summary: here is an 'immediate' dental implant requiring no drilling or bone augmentation (ie. surgery-free), that can be placed in minutes, and - once healed in - has no risk of future infection (peri-implantitis). Clinically proven over 10 years. Revolutionary, right?
No top-end journal is willing to publish papers on this topic. (We surmise that the implant industry profits too much from existing treatments.) We've approached several popular science magazines with article proposals; declined. Reached out to journalists, no response.
The only real publicity so far has been through word-of-mouth and SEO. It's a baffling (and somewhat disgraceful) situation. There are hundreds, if not thousands, of patients suffering needlessly every year, and a solution exists - but where is the bridge that can connect them?
More worrying yet were responses from implantologists and dentists on community sites such as Dentaltown. There was a shocking level of ignorance about osseointegration and zirconia, and a belittling attitude to such a 'newfangled' treatment. (Of course, it didn't help that the CEO on our side has a very low tolerance threshold, and expresses himself with typical Austrian directness - to put it mildly...)
Some of them have their own clinics and can even fund research.
For example in France: https://www.lamutuellegenerale.fr/qui-sommes-nous/fondation/...
Titanium and zirconia both osseointegrate (bond to bone) extremely well. However, titanium is grey and this discoloration shows through gums. Zirconia is white - like a real tooth - so it's much better esthetically.
Some people turn out to be allergic to titanium. Zirconia is the best choice in such cases. (Zirconia is arguably the most biocompatible of all implant materials.)
There's a lot of medical literature about ceramic implants, but you can be assured that it's definitely at least on a par with titanium implants.
Brush teeth carefully once a day: small, circular motions that cover every tooth surface; it's the mechanical action that removes food debris and plaque. A light touch is crucial, so you don't damage gums. Spend about 15-20 minutes on this in the evening, either while watching TV, reading, or just lying back in bed. Don't floss too often, because that can also damage gums.
Anecdote: I had a small cavity on a rear molar. I completely stopped chewing on that side for 2-3 months(!). During that time I dramatically increased my intake of calcium (yogurt, milk, green vegetables, supplements). When I later returned to normal chewing, the cavity was healed. From the medical literature I've read, this doesn't happen. But in my case, it most certainly did happen.
Also while I agree that the best is not to get the cavity in the first place, what do you do once you have it? What is the latest technology in filler material and treatment?
I don't know about the latest tech, unfortunately. The doctor I worked with is a maxillofacial surgeon; any case requiring fillings would probably get referred to a regular dentist!
I had a look around your website and I really hope you're successful with it.
If I had heard of you when I was getting the implant, I would certainly have considered your service (assuming it's available where I am - there's no obvious way to find out?).
The lasers also came out. Check out waterlase, it is widespread now.
But we are talking about regrowing dentin and enamel! And Kings College London seems to have been working on this for a while. Your article from 2014 is about it.
What I want to ask any dentists here is why is PHOTO ACTIVATED DISINFECTION not being used? Where can someone get it instead of drilling and filling???
There are something like 40 MMPs and we don't know what they all do, but they're generally responsible for destroying tissue in the body. Normally this is a good thing, like when a wound needs to clear out cells for wound healing. But fluoroquinolone antibiotics cause the "upregulation" of these enzymes, possibly permanently through epigenetic changes, so the body literally eats itself over time. This is why teeth shatter, hair falls out, collagen disappears (wrinkles, skin damage), connective tissue dissolves (like the optic nerve, leading to retinal detachment / blindness), and tendons literally snap without use, which can lead to disability. All of this damage can be irreversible even at low doses of fluoroquinolones.
Tendon rupture and retinal detachment are well documented.
There are also many reasons why side effects from these drugs are under-reported and under-studied. For example, fluoroquinolones have been around since the 70s, but the first case report of tendon rupture did not appear until 1983. After all, who would believe an antibiotic would cause a tendon rupture up to years after taking it? Doctors to this day do not usually believe that patients' spontaneous ruptures are caused by fluoroquinolones, despite being well documented in the scientific literature now.
MMPs are involved in many diseases, including fluoroquinolone insidious poisoning. They are implicated in heart disease and neurological disease like MS, for example. They are also implicated in general aging, because they destroy collagen which is considered to be irreplaceable in the body (hence why wrinkles are permanent).
Doxy is a known MMP inhibitor which may have benefits extending past its antibiotic range.
An important related question is why are MMPs upregulated by fluoroquinolones? One answer is that TIMPs are downregulated [1]. TIMPs are the antagonist to MMPs, they bind to MMPs and deactivate them. This is one way your body maintains MMP control.
Researching TIMP upregulators and MMP downregulators may help people suffering from permanent fluoroquinolone damage (like myself) deal with the constant pain and tissue destruction. These also have implications in aging and anti-aging technology. Notably, food from the ocean is well known to balance TIMP/MMP regulation [2]. Some natural antioxidants may also have the same effect [2]. This unexplored research is important both for tooth decay like the original article (since MMPs eat dentin, the hard tissue in teeth, and apparently enamel as well), and most tissue in the body, as fluoroquinolone sufferers experience in a hellish, constant reality.
[1] http://www.mltj.org/materiale_cic/704_3_3/6081_new/article.h... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707034/
I can't say it's cipro related. The stuff that happened was: very bad digestion, chronic left arm pain due to typing in a poor ergonomic position, and a bike accident + broken tooth (this clearly wasn't due to an antibiotic). I did, however, likely acquire MRSA in a wound on my chin that I got during the bike accident (I found out I had MRSA five years later; it had moved to my nose and persisted there at an asymptomatic/occasional flare up level). MRSA seems linked to cipro usage. I also acquired tinnitus at some point, most likely after the bike accident. My liver enzymes also tend to be on the high end of the normal range or slightly above it.
May have started bruxism that year or the one after, but it's hard to date when teeth grinding started. That one could be something that developed after the bike accident.
Nothing necessarily specific to cipro. But, supposing it did contribute to any of that, is there a normal protocol to reverse effects? Beyond what you wrote above, which would be: eat seafood and certain antioxidants (which?)
I'm in a pretty good state right now, and also nowhere near certain Cipro had any impact on me. But, it was a very rough year, and I had always been in excellent health prior to that. So if there's some sort of low side effect thing I could adopt such as certain foods, it's worth trying.
btw, here's the source on cipro and MRSA. I hadn't know about this link: http://www.news-medical.net/news/20120921/Ciprofloxacin-use-...
Muscle problems, especially muscle twitches, are very common among FQ toxicity sufferers. This is suspected nerve damage but there may be other factors.
FQs are well known to cause tinnitus, with the suspected biological mechanism being nerve damage to the ear.
Unfortunately, the medical community is severely lacking in treating these conditions, so there are no reliable tests for determining the underlying damage. It may be impossible to definitively know if any of these things were caused by the cipro.
A doctor who examined my tinnitus actually suspects it's nerve damage. However, it may well have been due to the bike accident, so it's hard to tell.
No muscle twitches that I'm aware of. More tension.
Now I check. A few months ago I rejected a prescription of Levofloxacin from a new physician, and had him replace it with an antibiotic from a different class that I knew I tolerated well. My pharmacist agreed with my decision. She had taken Levofloxacin for a few days several years ago and it gave her permanent neuropathy in her hip and leg and balance problems. Actually, she said the neuropathy was permanent "so far." For all she knew it would go away, but after three years she wasn't expecting it.
Note that I'm reporting an n of 2 here. My brother says Cipro doesn't bother him at all. Do your research and make your own decisions.
It's important to understand that taking these drugs once without reaction does not mean you are safe taking them again. There are plenty of horror stories of people not experiencing side effects until their 2nd, 10th, etc dose. It's playing russian roulette with death and a living hell. This is not hyperbole, unfortunately.
Well, one company , oragenics was ready for clinical trials. But it seem[1] that, due to a very restrictive enrollment criteria they couldn't enrol people to their clinical trial.Due to that and to further uncertainity due to fda , they stopped the clinical trial waiting for "partnering opportunities".
Such a shame. I wonder how and what could restart that project ?
[1]hsprod.investis.com/site/irwizard/orni/ir.jsp?page=sec_item_new&ipage=8899679&DSEQ=1&SEQ=19&SQDESC=SECTION_PAGE&exp=&subsid=41
The link you cite is not a vaccine, but a supposed 'replacement' bacteria that outcompetes the native bacteria [2]. This can definitely work, but I'm doubtful it will be universally effective, for the same reasons that probiotics don't always work: every person has different existing populations of bacteria, and not every invading species will be successful at colonizing or dominating that environment.
Yeah, but not many. Next to the ~half-dozen-hundreds-or-so of species populating our oral cavity without issue (indeed contributing just fine), we know of just ~under-half-a-dozen-or-so potentially dangerous ones. The very ones who create the very few actually damaging acids (among the many kinds in the world that our initially-generally-robust dentition handles just-fine) when fermenting carbohydrate leftovers. Brushing regularly disrupts or may even destroy their biofilm, Xylitol accomplishes/contributes the same FWIW, or absent dietary carbohydrate (read, ancestral ice-age hunters / traditional inuit / Maasai warriors etc) the problematic sort doesn't even ever form.
The researchers also have filed for a patent https://www.google.com/patents/US20140186273
2. FUD is using false information to spread fear, uncertainty, and doubt. When someone claims nutritional supplements have some sort of miraculous medical benefit, that is FUD. It is FUD because it is almost certainly false information and it helps to create doubt and uncertainty of mainstream medical science.
3. If OP provides empirical evidence that using nutritional supplements regrows enamel, I will admit I was wrong. The wider medical community would also be very interested.
Sucrose https://mega.nz/#!QYBk3KiJ!_72HCKWQwvFnosXpCxmH1fi80wXyLJhht...
Sugar https://mega.nz/#!kVx0gY6R!nlMy1VqAKGHiEembU1nbTFxCNICgHZEB2...
Carbohydrates
https://mega.nz/#!0M5F1JAQ!NCeWcjurUqhf5lw-ZIeCjBR-9hknt_Ehy...
Fluoride
https://mega.nz/#!JBJEkDTI!lhLPyHnNuLylN6SLETs6rjxBxk4Ho_pPz...
Diet
https://mega.nz/#!tc5RwKLK!gnQ1aN29YK5PLmiVV0mKqGJXshfCEjZgm...
when i came back, i had issues. but the imaging was really quite a bit better. the adhesives were better. the crown construction process was a lot better. cleaning processes much better. filling materials substantially advanced. mold making considerably advanced.
everything was substantially less painful, cheaper, and more well understood. maybe you can fault it for not being better faster
http://www.smile-store.eu/prevdent-re-whitening-and-enamel-r...
> "The nano-hydroxyapatite is a revolutionary material with a wide use in dentistry. With regard to restorative and preventive fields, nano-hydroxyapatite has remarkable remineralizing effects on initial lesions of enamel, certainly higher than traditional fluorides used until now for this purpose."
Apagard Premio toothpaste 100g | the first nanohydroxyapatite remineralizing toothpaste -- https://www.amazon.com/Apagard-Premio-toothpaste-nanohydroxy...
I wonder how much existing practices, who are invested in repair and especially cleaning of teeth feel about possibilities to permanently repair teeth. There are other advances such as the one with laser stimulation.
We won't be seeing anything in practice for another 50 years by what some of them claim.
1: http://www.dentistryiq.com/articles/2016/07/the-dos-and-don-...
Think of the lawsuits :(
I doubt that this makes much of an impact. Cavities aren't really a money maker for dentists and inadequacies inherent to the repair process mean that you'll almost certainly need more expensive work later on. The only way to really "beat" the dentists is to avoid enamel loss and calculus formation through proper cleaning technique and regular dental cleanings.
https://www.animated-teeth.com/dental_insurance/a-dental-cos...
Most dentists in the US are private practice which makes for a competitive market that prides itself on the quality of its customer care. If you really want to be worried about someone coming to take your hard earned money I'd be concerned about the growing incorporation of dentistry offices in the US.
http://www.dentaleconomics.com/articles/print/volume-105/iss...