I wonder - have you ever tried weed? With a few foreign molecules in your system you can go from barely liking cookies to consuming 5 boxes without being able to stop. The satiation part of the brain is very sensitive. Imagine having to constantly fight similar urges because of slight mutations in that zone. I think physical make up could be indirectly the most important factor in determining weight, especially when it comes to extremes like obesity.
edit: reworked phrasing