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Maybe my Handbrake installation was broken because of defective RAM - I don't know exactly... anyway: I found the problem was RAM and now it works...

It's actually scary how much (unpredictable and maybe undetectable) stuff can happen due to bad RAM.

I once had a bad RAM socket. I sent back RAM that failed memtest86 and was rather confused when the next set failed in the same way.

Yeah! Bad bit baked into the executable is a strong possibility.