I have tried to make use of Webpack a few times for my projects but the only times I have actually managed is when starting on a new project with a boilerplate and config generator. The way it is set up doesn't seem to meld with my way of thinking at all.
I really like how straight forward Browserify is. Likely this is because I am quite accustomed to Unix shell tools and makefiles (I actually use Ninja [1] with ninja-build-gen [2] for a few of my Javascript projects) but Webpack's hot-reloading would be really nice to have.
I do think it would suffice if Browserify was a bit more performant so I don't have to wait for it after making a change. I keep meaning to try Rollup to see if it will give me any advantages in that regard.