The Proposal of the Neutrino (1930)
fermatslibrary.com
fermatslibrary.com
'Pauli earlier (in 1930) had used the term "neutron" for both the neutral particle that conserved energy in beta decay, and a presumed neutral particle in the nucleus, and initially did not consider these two neutral particles as distinct from each other'
Clearly we need to throw the theory away and start from scratch.
[this being the internet: /s ]
The epicyclist in this case was Bohr - his idea was that maybe conservation of energy is just a suggestion.
Reines was awarded a Nobel prize in 1995 for the discovery.
https://en.wikipedia.org/wiki/Command_and_Control_(book)
It starts out where those weapons and prototypes from World War II were sitting on a shelf in a hut in the middle of the desert with no real security. That program had been all but shut down, the team disbanded.
Equally interesting is Stalin and the Bomb which covers the Soviet efforts to replicate what the Americans had created: https://books.google.ca/books/about/Stalin_and_the_Bomb.html...
There's accounts of scientists painstakingly re-discovering fundamental things only to realize their superiors already knew the correct approach to take, their intelligence had stolen the files, but were concerned that the information was faked to lead them astray. They must have felt like high-school students getting their homework checked by the teacher.