I remember thinking in terms my "screwed factor" and how I could make the most money with the least work back when I was in college and my first post-college job.
I found that it just wasn't worth it. I wasted more energy on micro-optimizing my time than I saved, and ended up being less successful. Plus it always just made me feel depressed, enervated, and vaguely guilty.
I'm working for The Man now, a large tech corporation. My stock options are a miniscule fraction of the company's capitalization. My salary is decent, but probably less than I could earn elsewhere. I've already made the company more money than I'm likely to earn in my lifetime, and will likely see at most a few thousand of that in bonuses. I harbor no illusions about advancement or striking it rich through climbing the corporate ladder.
And y'know what? I don't care. I'm happy now. I'm doing stuff that I'd want to be doing even if I were financially independent. Maybe that makes me screwed, but it seems to be working out fairly well for me so far.
I find that it's worth figuring out the big things, and then not sweating the small stuff. If you have a great marketable technologically-feasible idea, go found a startup and do that. If you don't, join a company where you can feel good about however many hours you spend there. Don't sacrifice things you really care about for work, but don't keep score either.