If there were some other fundamental means by which reality might be modified besides the basic interactions we know, our standard model of particle physics couldn't work so well, right? So to our knowledge, interaction is the one and only thing that puts a thing into existence or not.
As a side note: that is also the reason why WIMPs (weakly interacting massive particles) are a candidate for dark matter. The idea is that there might exist a form of matter that only interacts very weakly and thus it is incredibly hard to confirm its existence. Furthermore these WIMPs are massive (compared to other known elementary particles), so they might be out of reach of our particle accelerators.
These kinds of predictions follow from that.