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So what you're saying is that the mice that didn't have their genome edited didn't have a drastic life extension? I assume the improvements only occurred in the mice that had their genomes edited to reduce Yamanaka factors because they then artificially replaced the Yamanaka factors?

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No. That's not quite what I'm saying. There was no particularly interesting effect of inducing transient expression of the Yamanaka factors on normal mice reported in this paper. It is effectively a negative result that's being reported, as it pertains to wild-type mice.

The paper primarily reports results that pertain to mice with a genetic defect that causes progeria. Mice with this defect have a shorter-than-normal lifespan.

so its more a treatment for progeria than general aging reversal

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