(function() {}).__proto__.toString = () => "Hi!"
All functions use same __proto__ object (including functions that haven't been written yet), and it can be edited from anywhere in your program. (Tested in chrome 54).At a meta level, if you're trying to run trusted code in a JS environment that has some untrusted code in it too, you're going to have a bad time. The same is true in native programs by the way - you can't protect your program from a malicious library you're running in process.
The right way to solve this is to stop sharing a JS environment with libraries you don't trust. I don't know how you can protect yourself from malicious extensions, but you can stop pulling in a kitchen sink of JS libraries by being super selective about what you pull in from NPM. (Which you really should be doing anyway.)