I am currently running as a single founder, no employee, μISV.
It's possible, but here's what I have found:
- Partner with resellers who take a commission on sales -- then they can deal with all of the customer management.
- Set realistic goals for uptime, machines go down (it's not if but when), distributed setups are possible and encouraged for larger customers, but they cost more.
p.s. Wanna get a slack channel for solo founders going?
EDIT: I've created a slack group - Email me if you would like an invite!