Pro tip: If you want a reply to your application, try to avoid cold emailing hiring managers your resume. Often my inbox has a lot happening, and I'm not inclined to spend time copying your resume into our hiring software unless there is something spectacular about your email or background. Emailing hiring managers out of the blue also will not help you bypass any steps in the hiring process.
By filling out the application form on our website, you load all the information into the form for me, and are guaranteed that a recruiter will follow up on your entry. If you want to send an email to the hiring manager as well to explain why you are so awesome, that's fine, but it's probably not going to help your chances of getting a job any more than just applying.