Is this on topic?
On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity.
Our software development work is meaningless in the grand scheme of life.
This is a tool for presenting things meaningless. One can also say any sort of philanthropy and medicine as a whole are meaningless as we'll all die eventually.
Sounds like HN to me.