The places I feel where I know the cashiers and employees are not large supermarkets though, but small time specialty shops (the Polish butcher shop near my house, the florist, etc). To me large scale supermarkets (wal mart, target, whole foods, etc) tend to have young or post retirement, disinterested staff that are simply there to make a little extra cash and go home. Besides, there are often 10-15 cashiers on a schedule with ridiculous turnover. I don't see this competing with the specialty shops and thus not erasing that social connection involved in some shopping. Rather, it will reduce the drudgery and annoyance of going to huge grocery stores with no personal connection and a disinterested staff.
IMO non-specialty grocery stores with a few staff closely knit in the community have already been mostly eliminated by the larger corporations.