Those ideas put you - if you believe in them - in a spot where you can learn nothing about the world. There is nothing that allows you, even in principle, to figure out if there was a universe before last Thursday or if there is a world outside of your mind. There is not much more that would allow you to figure out whether the universe is a simulation or not.
Many people talking about that idea suggest to look for indicators of limited computing resources, rounding error or whatnot. But that is totally misguided in my opinion because it presupposes that you know what at least one of the two options, the universe or a simulation of it, looks like.
Who is to say that the laws of physics of the universe do not look like they are using floating numbers? Who is to say that a simulation of a universe may have to deal with limited resources? The outside world could be so foreign to us, time, space and laws of physics may not even be a thing there. Realistically the only way to distinguish between a real universe and simulation would be if the owner of the simulation told you in a pretty obvious way like with small serial numbers printed on all the electrons.
I kind of understand that people don't like the idea of not even seriously considering a substantial class of ideas that are not in conflict with what we see and that could therefore actually be correct. It also seems not very satisfying to throw some probabilities at them, last Thursday, unlikely, a simulation, totally reasonable thing to do, pretty likely. In the end, if it is not falsifiable, just ignore it and have one fewer things to worry about.