Maybe for some? I had been using an "ergonomic" Microsoft keyboard for years, but found that it was the amount of force and distance to depress a key that was causing me problems.
However, one fairly significant issue is that the top row uses buttons instead of keys. It doesn't bother me too much, but I can imagine that would mess with some people's workflows. Also the corresponding "ergonomic" mouse was the worst I've ever used. It's like a large ball that forces me to stretch and grip constantly to keep my fingers on the buttons. I replaced it almost immediately.