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Can't CRISPR achieve stable transfection through pathways like AAV, though? If that's the case, can't the cell lines carry on the changes without any need for on-going therapy?

Yup. You'd target sex cells instead, but that's only a slight modification.

GATTACA just relied on gene analysis (including among a number of blastocycts) but no gene editing. Though I was very annoyed at that movie for implying that people who get diseases just have insufficient willpower.

> We want to give your child the best possible start. Believe me, we have enough imperfection built in already. Your child doesn't need any more additional burdens. Keep in mind, this child is still you. Simply, the best, of you. You could conceive naturally a thousand times and never get such a result.

I always thought the editing was implied even if it wasn't explicitly called out.

Jerome was different in that he was not edited.

You're right that the text doesn't call it out but I was assuming PGSD[1] which would have the same practical effects and would be less controversial.

[1]https://en.wikipedia.org/wiki/In_vitro_fertilisation#Preimpl...

The "gene drive" - the quine of the genetic world.