USB hub? Many monitors have them these days built in. If yours doesn't, Amazon sells them for barely more than the cost of shipping these days.
Still, there's room on the case for additional front and back ports, and all the hubs I've used have had problems. It also defeats the clean look of the machine.
anecdata: I've bought more hubs than I care to count for multiple employers and not had issues. Also, the monitor hub route wouldn't affect the "clean look" of the machine any more than having a dozen cables sticking out of it every which way.