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There are. The Kinesis keyboard has four thumb buttons on each side of the keyboard. The biggest, closest one on the left side I map to CONTROL. The other big left thumb button I map to ESCAPE.

You can also look into importing a Japanese keyboard for more thumb options.

Why? Do the Japanese have more thumbs?

Sorry. Had to get it out my system.

I don't get it. . . .

They have two thumbs, but within reach of their thumbs are extra keys. They need these extra keys because there are a lot of characters in their writing. They don't need more thumbs, because they only need to push one of these extra keys at a time.

Do I need more pointer fingers if I need to use one of the Y, H, N, B, T, G, and V keys?

Um, it was a joke...

I remapped my keyboard so I can press CTRL with my thumb (it's where ALT conventionnaly is). No need to use pinkies and alternate between left and right CTRL!

I map right alt to ctrl. This gives you alt with your left thumb and ctrl with your right thumb, which is pretty intuitive once you get used to it.

i map capslock to ctrl using autohotkey