All I hear from that side of the debate is that somehow the government should restore prosperity to these regions. Why aren't these people moving to do something for themselves if they want change?
If all you can imagine your state being good for is low-skilled labor there is nothing the government can do long term to protect that. Protectionism might bring some "jobs" back but it will come at a long term cost of reducing the USA's competitiveness in the global market (this is exactly why globalisation is a thing).
Personally I think policy in Middle America needs to embrace the state of the world (putting aside petty coast vs interior bullshit) and think about what they can do to compete on a global scale. Then maybe their lives would be better.