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Can this be used on, say, Mario Bros?

You mean this script? Or machine learning in general? If the later then it has already been done: https://www.youtube.com/watch?v=qv6UVOQ0F44 (great educational video)

looking at the author's github profile he did a lib to abstract the artificial intelligence and used in some other games.

Deepmind's DQN (reinforcement learning) has been used to play Mario, learning from pure pixel data- http://www.ehrenbrav.com/2016/08/teaching-your-computer-to-p...