Yes, I strongly suspect that isotretinoin is responsible for my very soon after developing a chronic pain disorder and mood swings. After talking to others afflicted by chronic pain it turns out to be a rather common factor :( there's even a pretty plausible mechanism of action (to do with inflammation, which if you've ever been subject to the stuff, I suspect won't surprise you in the least...) Had I known about any of this (to be clear, I just mean the risk - not my actual outcomes. No predictions of the future necessary) prior to taking it, I'd never have considered it.