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I've been running Sierra for the last month or so and think it's on par with prior macOS releases. There's been no standout feature that's wowed me, but there haven't been outstanding bugs driving me crazy either.

Since I don't use the new Siri integration, I couldn't tell you a single difference between this and El Cap (maybe dark mode?)

I'm a .net developer running vs code and docker most of the time, for reference. I'm running on a late '13 rMBP.

I use macOS Sierra on my old Macbook Pro and I've had no Python development issues. I'm using a fairly standard setup with Python versions from Homebrew and virtualenvs.

I use the Homebrew Python2 and 3, and have had no issues. AFAIK not using the Apple Python helps. I actually jumped from Mountain Lion to Sierra and couldn't be happier software-wise.

Running Python and virtualenv, using Python 2.7 and 3.5 and Macports. No issues whatsoever.