I wonder how effective LZ4 would be as default compression algorithm for NTFS. It is extremely effective with ZFS.
I can't remember any other non-niche architecture with 8*2^n word size that shares this (mis-)feature. (I suspect that Cray 1 and it's derivates also share this, but that probably counts as niche architecture)
It's fine for OpenBSD or NetBSD to support it, but Microsoft has not supported it in a long time.