This is really just a war of opinions now, but the F1 keys are indispensable to me. My fingers rest on the hotkeys for "step into", "step over", "run to breakpoint" and I can keep my eyes glued to the watch list, inspecting the variables at each step. Some times you want to quickly step into functions, other times step over, and it's just really handy to have it mapped to keys.

I'm not even a power emacs user or something (IntelliJ is my preferred IDE). YMMV of course, but I find the hotkeys super useful.