We're trying to figure out ways to get around this for later stage seed investments. We don't have a solution yet, but we're working on it.
In a thread below I talk about file cabinet industries — industries that basically have no software, and are horribly inefficient. Investing is absolutely one of those, but only using email and calendaring. The main bottleneck for investors is number of hours in the day, because there are very few people making all the decisions. Warm intros are the only way a non-software system can work.
So, spoiler alert, software. :-)