I am more and more of the opinion that you should NOT use a js framework for long term projects (that span more than a few years), but just use vanilla js with some libraries that you can easily switch when something better comes out. Vue.js is here today, and it is nice, but tomorrow gintzx.js comes out, and the community will be flabbergasted and everyone will use it and vue.js will slowly die. Making big complex webapps with just some libs is absolutely possible. Just choose them wisely and make a good directory structure.