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What is this for? You can use the search API directly (it works with URLs):

http://apiwiki.twitter.com/Twitter-API-Documentation

If you truly want regex support, just grab a lot of tweets with the API, and filter client-side.

I am looking for an existing Twitter client that can filter by regex while still having all of the bells and whistles. Building my own would be a last resort.

Checkout Yahoo BOSS, you can whip up your own client pretty easily in Python or Ruby.

Reply on news.ycombinator.com