- Costs: In recent years it has become prohibitively expensive in the west to build nuclear reactors. Hinkley point C in the UK will have higher cost per MWh than wind or even photovoltaics.
- Nuclear waste: Many supposedly safe storage solutions such as in former salt mines have turned out to be unsafe. Gen IV reactors produce less, but not nothing at all.
- Security and safety: They're centralized infrastructure, attacking them has catastrophic consequences, unknown unknows like in Fukushima and human errors like in Chernobyl do happen and lead to catastrophes.