We decided very early on to use Relay for our main frontend (a dashboard similar in complexity to Parse.) It's probably one of the largest open source projects using relay atm, so maybe having a look at that can be helpful https://github.com/graphcool/dashboard
In summary we have found that the benefits Relay offer makes up for the quirks and complexity Relay currently forces you to learn. Hopefully Learn Relay can help more people get up to speed faster.