If one assumes Holmes didn't realize their product didn't work (questionable at best), imagine how it must be to work 7 days a week, forego friendships and intimate relationships, and not even watch TV, then after 12 years of that discover what you tried to make didn't/won't work. In too deep or something to just admit it's over and move on.

Sounds like a very undesirable number of years with little positive to show, although maybe there were some lessons in there. Maybe time for a workaholic recovery program for her, who knows. Sad to hear the prime of a life spent like this... though perhaps not any worse than other destructive paths one could travel.