I have no trouble at all "keeping up" with the "insanity" that is front-end development. If you're confused learning new things, it means you're learning.

At my company, we have moved a lot of our front-end code to eslint-checked ES6 with some plugins, writing react/redux powered interfaces. New hires generally learn the codebase fast, you're well protected from shooting yourself in the foot thanks to type checking and linting and the absence of globals. Our team is many times more productive with this stack than with the es5 + knockoutjs code we built with before.

If you're building a hobby project, just start with a <html> tag with inline ES5 and css, and refactor and iterate from there. Use server-side templates. "keep it simple". But when building client-side interfaces at a higher complexity level, React is king.