One advantage of uMatrix: You can filter based on host-destination pairs.

That is, in NoScript you can only filter based on the destination. For example, if you allow one site to run scripts from cloudfront.net, every site can. Effective the rules are,

  DENY  * *
  ALLOW * cloudfront.net

In uMatrix, you can write rules based on host-destination pairs, permitting scripts from, e.g., cloudfront.net to run on your bank's website but not on any others:

  DENY  * *
  ALLOW mybank.com cloudfront.net

Finally, you can filter by host & destination & function:

  DENY  * *
  ALLOW mybank.com cloudfront.net JavaScript

... which would not allow plugins, images, CSS or anything else from cloudfront.net, only JavaScript.

EDIT: Add, improve examples