Ahead-of-Time Compilation in Angular 2
blog.mgechev.com
blog.mgechev.com
I'm not sure about "most", its relatively new amongst currently popular frameworks.
Assuming I understand correctly that the script execution time figures he provides are for the angular-seed app, what _is_ insane is how much time is spend executing JavaScript for what is a very simple application.
By having a framework which is very large and contains a lot of code in the first place, you then have a lot of work to do to try and recover from that volume.