If someone is born with down syndrome, they are extremely unlikely to graduate from university. If someone's eyesight isn't perfect, they will probably never become a commercial pilot. If you're autistic, you probably won't become a professional negotiator...
There are so many cases, sometimes rooted in tiny genetic differences which can make a huge difference when it comes to winning and losing...
And when you take luck into account; you could argue that even the most genetically fit human for a specific field is unlikely to become the best in that field even if they practice non-stop. There is so much luck involved, a single tiny problem can ruin an entire career before it even starts.