Haha good question.
Yubico has a good explanation:
https://www.yubico.com/products/yubikey-hardware/fido-u2f-se...
It's the same as any other U2F token. You register it with a service that supports U2F (Google, Github, Duo, etc.) and then present the token and press the button upon logging in later.
No software or drivers needed. It's an HID device so all normal operating systems will support it.