On that, in 2, the author talks about Brain Simulations and states that it'll take up to 500 years. I think that is a good upper estimate actually. Though optogenetics is a great tool, we need more. Mammalian brains can be up to 50% (at the low estimate, some say 90%) made out of astrocytes and glia. We know pretty much nothing about how they affect neuro processes, outside that they do, sometimes. We do know that is a huge problem with our understanding though, which is something I guess. Optogenetics should help tease out some of those glia methods, but as usual, it will raise more questions than answers. Another issue is potentation and its molecular mechanisms in more than just the hippocampus. That work is incredibly tough, but we really only focus on the anatomically 'easy' areas for memory. We have to do more to understand. In short, we don't even know the correct questions to ask when it comes to the brain and understanding it. A full simulation, or a '80%' approximation even, is a few paradigm shifts away still (maybe, we cant know yet). It will likely have to be a 'full world' simulation too, where you have to control all the inputs to the brain and therefore have to model a world first. The brain's best feature is that it is all connected and a giant spaghetti mess. This is, obviously, a long ways away.