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Comment by forloop | Hacker News Reader

You sound like a follower of Ray Peat. He recommends MB, holds that position on fish oil, recommends K2 as a quinone, recommends aspirin, and recommends nicotinamide* (for the NAD+)

From what I can tell—and having experience with MB & his diet)—he's full of shit.

* You should look into that. Nicotinamide inhibits the sirtuins. You'd probably be better off with nicotinic acid or nicotinamide riboside (NR).

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It's VERY easy to make up your mind following a comment like "he's full of shit", but for anyone reading, I suggest you look at at these two articles by pranarupa:

https://pranarupa.wordpress.com/2012/12/25/pufa-because-this... https://pranarupa.wordpress.com/2013/01/31/serotonin-inflamm...

To me, Peat's notions on PUFAs and serotonin are the most important ones to grasp.

I agree. People should make up their own minds.

When I see studies like the following (grabbed from Dr. Rhonda Patrick's Twitter feed) it makes me question his position on fish oil.

I also found fish oil beneficial to my recovery process, after I got cognitive problems following MB.

Studies:

* Study links omega-3s to reduced mortality[0]

* Consumption of omega-3s linked to lower risk of fatal heart disease[1]

* Lower risk of bowel cancer death linked to high omega 3 intake after diagnosis[2]

* Omega-3, omega-6 supplement improves reading for children[3]

* Stroke-like brain damage is reduced in mice injected with omega-3s

[0] https://www.eurekalert.org/pub_releases/2016-06/g-slo062216.... [1] https://www.eurekalert.org/pub_releases/2016-06/tuhs-dco0623... [2] https://www.sciencedaily.com/releases/2016/07/160719214830.h... [3] https://www.sciencedaily.com/releases/2016/09/160914085808.h... [4] https://www.sciencedaily.com/releases/2016/08/160822140534.h...

I was convinced by the advocates for Omega 3's. Then my dogs destroyed my cofffee grinder (used to make flax seed meal), I realized that I'd never noticed a benefit, and stopped.

The modern diet is overloaded with Soybean Oil, an oil which should only be used as biodiesel. It takes years of a low-PUFA diet to obtain all the benefits. Some degree of temporary relief may be provided by Omega-3 supplementation, but this intervention doesn't address the cause of any condition.

He's full of shit doesn't exactly convince me, when I look at his amazing coherence, all the wonderful books he's written, hundreds of articles, newsletters, and his general seriousness and disinterest in popularity. One or other thing he's recommended (always backing himself with references and studies) may not have worked for you, but dismissing him like that to me only shows short-sightedness. Would love to hear you elaborate on it. https://vimeo.com/135920003

"In the last couple of years there has been a lot of "noise" in the media about how the SIRT-family of genes can extend lifespan when activated by things like exercise or, preferably, by certain chemical compounds like resveratrol (which putatively acts on SIRT-1). Ray Peat has stated his opinion that activating those genes is not likely to lead to life extension and may even be implicated in some cancers. In one is his articles he talks about how niacinamice/nicotinamide (vitamin B3) acts in a way approximately opposite to resveratrol. Also, there are independent studies that found niacinamide silences SIRT-1 and SIRT-2 in high doses. An interesting study came out recently that seems to corroborate Ray's views. It looks like it's niacinamide that actually extends life while resveratrol so far has been a bust (several clinical trials halted due to resveratrol increasing mortality in patients)."

https://raypeatforum.com/forums/threads/sirtuins-and-life-ex...

I heard that sirtuins are beneficial for a healthy organism, and could be detrimental to someone with cancer. The same goes for something like glutathione (since they make cells more robust, and you don't want robust cancers cells!).

I've read anti-agingfirewalls.com with great interest. Here's one of the articles:

"PART 3: Slaying Two Dragons with the Sound of Silence: – How to Keep Your Repetitive DNA Turned Off with “3 Songs”: Sirtuins, Polycomb Proteins, and DNMT3. And a Master List of Drugs and Natural Compounds for Cancer Chemoprevention"[0]

Anti-ageingfirewalls.com is a tour de force. And it's at least worth reading the earlier articles (some of the recent articles on NAD require significant knowledge).

As far as I can tell, Peat contradicts the consensus. I've tried his methods, and had terrible results. He also goes against the information I'm exposed to. He may be correct, but I assign a tiny probability to that. I wouldn't recommend anyone start with Ray Peat.

[0] http://www.anti-agingfirewalls.com/2013/05/20/part-3-slaying...

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