I take alcohol and caffeine (and sugar!) but consider doing it batshit crazy, as most people do: there are very few articles explaining how these substances could be good for you. They are not. The fewest drugs the better, let's not try adding more.
Hang on now...most people find consuming caffeine and alcohol batshit crazy? Do you live in Utah or something?
Last I checked, caffeine in moderate doses has a mixed bag of positive and negative effects that's not clearly net negative.
There's controversy around whether moderate alcohol consumption (think 1 drink/day) has a positive effect. (Some studies say it does, but it's argued it's a statistical anomaly because people who don't drink at all are weird, e.g. former alcoholics, people with medical conditions that forbids them any alcohol, etc.)