The 80 / 20% rule applies once more - why spend 80% of work on the 20% of users that would benefit from progressive enhancement? Unless those 20% of users generate 80% of revenue, which in all likelihood they don't.
A rephrasing might ask why we make technology choices that exclude 20% users?
If we're not able to produce a single page web app that reaches 100% of users, that's cool... just make a many page web site without lots of JavaScript that does.