> Current thinking is that nicotine isn't "addictive" unless coadministered with monoamine oxidase inhibitors, which happen to be present in tobacco

This is a most-helpful comment. Thanks!

I commented earlier today [1], in another submission, that nicotine is rather similar to Niacin (Vitamin B3). Niacinamide has helps my girlfriend reduce her tobacco usage...

[1] https://news.ycombinator.com/item?id=12526802

The first anti-depressants were MAOI's. Some of them caused a serious side effects (high blood pressure) when the patient consumed fine aged cheese at the same time. When the SSRI patents came into effect patients were switched to the new drugs, but not because the SSRI's worked especially well.