Comparing the two situations I'd argue the business option is far better for a number of reasons. The most important being freedom. To survive in academics now is an awful game of proposals and nonstop stress. Success rates are very low and there is intense competition. And all for very little (no) payoff. And it is a sales job. At the end, before I finally pulled the plug I often likened academics to a situation where you're selling something that people may like, but they don't want to pay for it. If you do it right with a company, people are begging to pay you. And the reality is the business route is much more challenging, just in a different way. Everything is on the line.
I do think promoting a "startup" in the conventional sense where you have VC funding and explosive growth is disingenuous. There are many opportunities where a PhD scientist can carve out a niche where you have a company with 1-10 million in revenue. It affords an excellent situation that, if sustainable, is orders of magnitude better than the academic lifestyle that is so often idolized.