If you think about it, any molecule that isn't sugar but tastes like sugar will have a similar molecular shape to sugar. Hmmmm I wonder if this will fit into receptors in other places in the body, not just on the tongue. Maybe it will affect gut bacteria. Maybe even trigger other events within our bodies.
If we would stop and think with an open mind, many of these arguments would become discussions, and we wouldn't need to play the baby card by asking for proof.
Remember how long it took to finally get enough proof in order to show others how wrong our mainstream religions are? And even with all the evidence we have accumulated, still people say, "show me the proof. I'm a reasonable man." Bullshit.
Let's not fall into this trap again. Many of these questions can be answered without slow, hard science. We don't need to hit everything with the biggest hammer in our toolbox before we can move forward.