The US placed cathinone on Schedule I in the 1990s. This effectively banned khat, a relatively harmless stimulant plant, chewed as a recreational by northern African / Arabia cultures for centuries with little harm.
Fast forward 20 years and shady chemists learn that it's possible to take the structure of cathinone (as a basis), tweak it here and there, and come up with purified "substituted cathinones". AKA: "bath salts" (MDPV), mephedrone, methylone, and countless others. Some of these were frankly nasty.
Today, the US decides to ban kratom, which has been naturally used for recreational purposes in Thailand and elsewhere in Southeast Asia for centuries.
I wonder if substituted mitragynines are in the future. Very possibly. If not from the pharmaceutical companies then from future sellers of "bath salt" type substances.
Either way, there's something very culturally insensitive about these type of bans, in my opinion -- these laws carry a whiff of "these are drugs that these other people do". In today's drug enforcement culture, apparently the khat cafe is horrible, but the pub and the coffee shop are a-okay. Personally it's hard for me to see what the difference is between the two, except the pub / coffee shop are accepted by well-off Western Europeans, and the khat cafe is mainly populated by poor Somali / Yemen / etc. immigrants.