The one problem with using Clojure on App Engine is that the time for a "loading request" is at least 5 seconds. It makes your app look bad for the random user stuck on the loading request.
Anyway, are you being serious (i.e., in your experience is clj+gae noticeably slower than java+gae or python+gae?) or just funny? Since I've never done any serious profiling of Clojure on GAE, I'll bite and do some brief performance tests and report back.
I'd like to run some benchmarks for normal requests, where I doubt there'll be any real difference.
Thanks for the search.