Qt has a truly pleasant API and bindings in many languages. If you haven't used it before - and I know you haven't, otherwise you wouldn't be asking :) - give it a try. There's very little that's more cross-platform.
However there's a bit of a UI rendering overhead, although I understand they made it faster with Qt 5.7. And OpenGL integration is more complicated than doing it natively since you have to understand Qt's UI scene graph system and the way Qt is threading things.
But overall it's been a good choice so far.
I used QT before. Please don't be presumptuous.