How Parents Harnessed the Power of Social Media to Challenge EpiPen Prices
well.blogs.nytimes.com
well.blogs.nytimes.com
The reason why this has come to a head is high deductible health plans. This is where you pay the first $1000-$6000 in medical costs before insurance kicks in. When all it was was a $30 copay, consumers didn't give a shit.
So maybe, just maybe, pushing more medical costs to patients will actually create the pressure needed to reduce medical costs? Interesting thought.
And instead of insurance companies, it appears Social Media mobs are being effective at collective bargaining, which in other countries outside of the US has shown to be effective at keeping prices lower. Unfortunately it's a very selective outrage.
What Mylan is trying to do is a bit sneaky -- mollifying the high deductible complainers by giving them a coupon they can use but I believe in the long run it will backfire since it will drive more people to high deductible plans.
low deductible health insurance plans dont make much sense b/c no one has an incentive to save money. by having people share in more of the costs (up to a certain level) I think you get market forces to help keep prices in check
There are competitors to the Epipen but they don't get prescribed as much. I would surmise that has something to do with marketing budgets. Maybe we should join the rest of the world and ban drug advertisements? Oh, and allow Medicare to negotiate a bulk rate for drugs rather than pay MSRP[1].
[1] https://en.wikipedia.org/wiki/Medicare_Part_D#Criticisms
In Australia we solved this by requiring pharmacies to offer generic alternatives.
https://twitter.com/drmarkporter/status/765569736423927813
> Q for SystmOne GPs: is there a simple way to ensure default drugs offered when prescribing are cheapest versions most commonly prescribed?
https://twitter.com/drmarkporter/status/765570038048911360
> For context: our default omeprazole version (20mg) is currently 5 times price of one 4 down. Easily repeated costly error when busy.
You don't have to keep up with the Rx industry to research different treatments and pricing for your individual condition. When I went to the dermatologist for skin cancer screening, she prescribed me Picato for my actinic keratosis. When I called the pharmacy and found out it would cost $200 after insurance, I called BCBS and spoke with their pharmacist about alternatives. She gave me a short list of brand names and generics, from $10 up, and at the end I decided to go with the doctor's Rx because it had the shortest treatment and recovery time. I did find an online coupon, however, which my doctor didn't tell me about.
There's no way a GP can keep up with everything that's out there. Less expensive remedies have no one to fight for them either.
The laws of supply and demand get regularly rediscovered <g>. A discouragingly large amount of government policy ignores supply&demand.
> over simplification
I suppose it's like "gravity" being an oversimplification of the bending of light around stars.
The Internet's attention span is 45 seconds on a good day, and that's not enough time to affect real change. Until this changes companies realize that all they have to do is weather the (brief) shitstorm until people move on to the next buzzworthy thing and then they can just go back to business as usual.
How many people know that the drug Martin Shkreli jacked the price on is still that same price long after he left the company? They never even did a show of putting it back briefly, the price was jacked up, Martin took the hate off the drug company that did it, and they kept collecting the money.
I don't think social media can affect real societal change because it's like trying to get an unmedicated ADD kid to do his homework, you can't hold his attention long enough to make meaningful progress.
That was one of purposes of high deductible plans -- to expose people to the prices.
In an ideal situation they would go search for more reasonable alternatives so create a market, but other, unintended perhaps consequence is it creates an outrage. So far, though, it is more of an impotent outrage. The stock went down from $50 to $45. That's not huge, it will recover soon.
The results of such an outrage is often the opposite -- other companies see and say "Ah, well, everyone else doing it without repercussions, we should raise our prices by 200% as well".
A comparable device, the Emerade Auto-Injector, made by Bausch and Lomb / Valeant, sells for £26.94 in the UK.[1][2] The UK, of course, has socialized medicine.
The company behind Emerade is more into cutting deals with other pharmaceutical companies than bringing prices down.[3] "Valeant’s strategy is to focus on the business of core geographies and therapeutic classes, manage pipeline assets through strategic partnerships with other pharmaceutical companies and deploy cash with an appropriate mix of selective acquisitions, share buybacks and debt repurchases. Our leveraged research and development model is one key element to this business strategy and will allow us to advance development programs to drive future commercial growth, while minimizing research and development expense."
[2] https://www.psuk.co.uk/everyday-items-disposables/dental-ins...
[3] http://ir.valeant.com/~/media/Files/V/Valeant-IR/documents/v...
"The Canadian price has remained constant for more than five years, thanks to regulation by the Patented Medicine Price Review Board, which has strict control over the prices pharmaceutical companies can charge for their products. In Canada, the auto-injectors can be claimed under most provincial drug benefit programs." https://www.thestar.com/news/canada/2016/08/25/americans-tur...
http://www.chicagotribune.com/business/ct-epipen-ceo-bresch-... http://www.nytimes.com/2016/08/25/business/mylan-epipen-sena...
This is terrible.
Wouldn't there be other good ways to ensure everyone has access? Eliminate the need for a prescription for instance? How does one go about doing that?
The CNN video that plays at this links says their margins were 9% in 2007 when the bought the drug and 55% in 2014.
http://money.cnn.com/2016/08/25/investing/epipen-cost-ceo-lo...
Any business with 55% margin is a nice business to be in.
It's also kind of scandalous that they've designed a method to reach around the insurance companies. I don't think drug companies should be allowed to offer consumers rebates that make them more likely to utilize their insurance. When they start from a high price, it's an accounting trick that doesn't cost the company anything. If a company so strongly believes they've miss-priced their product, they can simply reduce the price.
Going around the insurance companies is pretty insane, especially because there are multiple types of customers: individuals, schools, hospitals, etc. Should an individual get money back, but not a school? It's not like public schools have a bunch of cash lying around.
There's only 900 public schools though, so it's hard to construe lobbying for the laws as a meaningful expansion of their market.
What Mylan learned here is that they didn't have enough social media presence. I bet their had a meeting and didn't say "Yap we have been assholes about this, let's roll back prices and appologize" but rather "People feel we are assholes. Who is responible for our social media and marketing? Action item 1) need to allocate more funds and hire a better PR company".
The product costs a few bucks to produce, retails for $600, and not covered by patents: epinephrine discovered in 1901, the autoinjector is derived from military model likely in public domain.
How comes no one in the whole US wants to earn billions manufacturing a similar product and selling it for $50?
in which, they indeed do have.
What people don't seem to understand is - healthcare products are no laughing matter (literally). This isn't like software, where you can release early, release often, and where alpha quality is tolerated (to a degree).
For whatever reason, Mylan have done the FDA testing, and perfected a product that works reliably. That is expensive. (I suspect profit factored into it somewhere).
There's nothing stopping somebody for designing a different device (like Sanofi) did that does the same job - the devil is in the detail, and making sure you don't f_ck up.
Because believe me - the moment you screw up, and deliver the wrong dosage to some kid in anaphylatic shock, and he/she dies...your company is history (or facing a very costly recall and/or potential lawsuit).
My daughter recently had a health-scare. That moment, when I looked at her, and honestly thought she wasn't going to make it, was heart-wrenching. So I can tell you, as a parent, if my daughter was allergic to something, and the Epipen was $600, and I needed one around - sure, I'd be bummed about the money, but no, I wouldn't not pay it. And if you told me, these are the only guys so far who have made sure it's reliable, or you can get these cheap 3D printed copy that might work 85% of the time, or she might die but it's only $100 and realy, what's 15%?? What do you think I'm going to go for?
If this was like, say, something else that wasn't literally life-saving, then sure, people's risk appetites would probably change dramatically.
"Wrong dosage", though? Dosing epi isn't a particularly exact science - the adult pen is 0.3mL, the junior 0.15mL. Quite often we will have to use multiple pens on the one patient.
Underdose is entirely common - especially in civilian-administered situations. Overdose is typically restricted to acute hypertension and associated symptoms which can largely be managed by EMS (who should be enroute anyway for any admin of epi, for reasons not least of which include that 'need for additional dose').
> Sanofi US Issues Voluntary Nationwide Recall of All Auvi‑Q® Due to Potential Inaccurate Dosage Delivery > ... > If a patient experiencing a serious allergic reaction (i.e., anaphylaxis) did not receive the intended dose, there could be significant health consequences, including death because anaphylaxis is a potentially life‑threatening condition. As of October 26, 2015, Sanofi has received 26 reports of suspected device malfunctions in the US and Canada.
Or is it something that somebody like an EMS would probably not get wrong, but say, a non-medically trained panicked parent could?
I've heard the shelf-life complaints about Epipens.
For me, I figured it was pretty idiot proof, even for an untrained person in panick mode - take it out, stab it in leg, and that's it, as opposed to trying to drain an ampoule into a syringe. Fortunately, I've never had to face that bad situation....
There are some things that can be done to improve the effectiveness of EpiPen/equivalent administration - while the product is designed to be able to be used through clothing, it is better to be removed where possible. Due to the dosage size, post injection site massage is recommended for better uptake from the muscles.
When to administer is also another question - arguably by the time the patient is in significant respiratory distress, it should have been administered earlier. This can be a balancing act between a 'sensitivity' and anaphylaxis. Realistically, as soon as there is a deterioration into multi-system response, Epi should be administered.
Certainly, other than cost there's no real motivator for the lay person to need to be trained to draw up epi into a syringe. But in terms of ambulances / medic units who stock epi (typically used in cardiac arrest), the requirement to stock EpiPens is an unneeded redundancy, and an expensive one at that.
One of the biggest reasons is that it's not patent protected. Once a few generic versions hit the market, every manufacturer tries to grab market share by dropping the price. The price of a branded drug usually drops by 80-90% once the generic becomes available.
It looks like an attractive market right now, but once a few generics get launched, it won't be as attractive. Mylan is only making hand over fist because others failed to launch their copies.
Designing and testing a new injector is expensive and time consuming. There are certainly new devices coming to market, so the window for Mylan to make money is pretty minimal.
In the meantime, there are substitutes that are much cheaper. You can purchase an Adrenaclick from Walmart for $140.
http://www.consumerreports.org/drugs/how-to-get-cheaper-epip...
I genuinely have no idea why people consider there to be no viable alternative to the EpiPen - the only guesses I might have are that the third autoinjector (Auvi-Q) being pulled off the market being more "newsworthy", that insurances don't cover it (but $140 is a pre-insurance cash price!), and third but probably most important: people aren't getting prescriptions for something they're not used to using. I have never gotten a prescription for anything but "EpiPen" specifically.
http://www.nytimes.com/2016/08/24/upshot/the-epipen-a-case-s...
Source: my son has a severe peanut allergy and I have successfully purchased EpiPens for him at the Lethbridge AB Costco.
In short: Ship 'em.
This is one edge case but the overall picture is that drug companies own the government and ensure legislation is in place to give them astounding amounts of government and consumer cash.
It's a silent coup.
This year's election seems like a perfect time to re-think unflinching support for the two main parties in the US.
(1) It's better to be in a business where you don't (literally) save lives, because nobody complains about how much money the Pokemon game makes.
(2) People won't actually take a lot of risk to market and develop life-saving products without a financial incentive.
Epinephrine is not patented. The only thing stopping a competitor from entering the market is coming up with a delivery mechanism for the drug that's as reliable as Mylan's. Apparently that has proven difficult. Sanofi used to make a competing device, until it was forced to do a mass recall because the device couldn't deliver an accurate dosage.
The difficulty of getting it right is compounded by the fact that a device that delivers epinephrine to children in anaphylactic shock is just about the highest-risk product you can make from a potential liability point of view. There is no market for a "slightly less good but much cheaper" product.
This is one of the challenges with drug pricing. If you're pricing your drug to the benefit it offers (which is what is generally done), you better do it at launch or you're screwed.
This has actually happened with other drugs in the past. The drug company runs a clinical trial in one disease, gets good data and sets a price. The drug then gets approved in another indication where the value is much higher, so they try and raise the price to reflect the added value. Usually it results in outrage.
And that -after significant and hefty lobbying of legislatures to mandate that schools, EMS units (capable of managing, maintaining and drawing up epi themselves) and the like be required to carry them-.
http://nces.ed.gov/fastfacts/display.asp?id=84
So it's around 3-5% of their market ($600 per school is 2.5% of their $2.4 billion annual revenue on the pens). I guess that is a pretty substantial chunk.
The cost to market for the EpiPen was recouped long before Mylan even bought the company. This is just gouging. Believe me when I say that someone else will pop up as soon as possible (FDA approval takes a long time) with a product that costs a 5th as much, as long as Mylan doesn't manage to rig the system.
I agree that it's a not a price vs. demand equation since demand won't drop off for a product like this since there aren't really any substitutes (other than the vial and syringe which has limitations). However, public response to a price is a very strong motivator for drug companies. I can guarantee you that Mylan's C-suite is in a frenzy right now trying to figure out how to fix this.
Of course, we want strong requirements on life saving devices. Just a bummer it takes such an awfully long time.
Anyone know the longest pole schedule item in getting a new drug/treatment to market?
And countries, which put people before corporations, actually do this.
[1] http://www.patentdocs.org/2016/04/members-of-congress-seek-n...