I'm not an expert in front end technologies. Mostly done C all my life and now Java. But, when it came to jumping on to JavaScript and writing Web Apps, I choose Typescript. I don't know what most of the people think about it, but for me it was more about code readability. I can look at Typescript and tell what's going on. Couldn't do this with regular JavaScript.
http://www.typescriptlang.org/play/