I've been trying to like pkgsrc on Mac OS X for a few years now. The one you link to provides binaries, and is sponsored by Joyent. The main deal breaker for me there is that they only update their packages every quarter (currently 2016Q2), so you have to wait if you want bug fixes, security updates, etc.

I just had a look again and found that ffmpeg is one minor version behind behind stable, its binary is annoyingly called "ffmpeg3", and it was compiled somewhere with LLVM 6 / clang 600, versus LLVM 8 / clang 800 on my macOS 10.12 system. I tried to compile it manually (after a shallow clone of their massive, 250,000+ commit git repo), but failed.

For me Homebrew does the right thing here — they basically turn my Mac into a rolling release Linux desktop like Arch Linux, which is great for the userland type packages I use: openssh, zsh, tmux, postgresql, ffmpeg, git, vim, rsync, etc.

Browsed the website for a while, but couldn't find out why anyone would use Pkgsrc over any other package manager. If you know I'd love to hear!