From the perspective of colonization: by the time future sentients descended from or created by present humanity get to other planetary systems, we-for-some-definition-of-we would be capable of living anywhere, and space and novelty will be things that you get by computing more efficiently, not by going places.
From the perspective of adding data to the Fermi Paradox: assessing the possibilities of life being out there by looking for places in which bacteria of the known varieties could survive probably tells us little about the true range of life.
From the perspective of resource assessment: by the time descendant entities get to other systems, it won't much matter how the matter there is distributed. It will used efficiently whether a gas disk, rock and ice condensations, or (improbably) somehow all in the star.