Nanorobots That Can Travel Down the Bloodstream and Precisely Target Tumors
sciencenewsjournal.com
sciencenewsjournal.com
https://media.nationalpriorities.org/uploads/discretionary_s...
http://www.usgovernmentspending.com/us_budget_pie_chart
Showing that abbreviated 'discretionary spending' subset of the budget is uninformative at best; dishonest at worst.
Congress has control over the whole budget. Unlike, e.g., the California Legislature and voter-mandated Constitutional spending in the state budget, there are no "mandates" in the "mandatory" part of the federal budget from some authority that transcends Congress, and it is well established that past acts of Congress do not bind future Congresses, or even future acts of the same Congress.
> Furthermore the mandatory portion (entitlements) are fundamentally different - you pay into the system through payroll taxes and pay out later during retirement.
That's not entirely true. While mandatory spending does include the payroll-tax-funded Social Security and Medicare programs, it also includes programs that are funded from general revenues like Medicaid, SNAP, EITC and the Child tax credit, etc.
https://en.wikipedia.org/wiki/DARPA
Notable ones that caught my attention: internet (ARPANET), satellite navigation (transit), time-sharing computing (multics), onion routing (Tor), the computer mouse (Engelbart), autonomous robots (Shakey), and self-driving cars (Grand Challenge).
With better and fact-based education we can solve a lot. I don't mean training for jobs, I mean education as a means to, say, reduce killing each other or making more efficient use of earth's resources.
For instance, the best way to fix the problem of people flocking to extremist leaders is more education on all sides. The unknown is scary enough for many people that it's used for them to be led to believe simplified but factually wrong explanations for issues they face.
You're incorrect about what it presumes; valuing facts is something most people need to be taught. That's why there's always a push for education, otherwise you end up with Trumpism.
Telling people from another tribe that they are ignorant has never changed anything.
The biggest threat to their wealth would be a collapse of the current society -- the status quo -- and so, although they may have SOME material goods (okay, more than most others), the vast majority of the value of what that they have is merely on paper or "stock," whose value is determined entirely socially.
Of course, their value could vanish in an instant if society no longer believes in their wealth or the system that proliferated it.
Granted, it would take a "total collapse" (and resultant lack of faith in our economic system) for this to happen, but historically, societies don't fail gradually or softly, they implode.
A real life example of such a loss of "faith" in a massive quantity of wealth that isn't civilization-scale such as the fall of the Roman Empire (as recent in history as it is) on an individual-scale would be Theranos and the instantaneous deflation of Holmes' net worth from a socially propped-up "cool billion" to zilch.
People en masse generally don't take too well to mass corruption. Over history, the average lifespan of a social empire has been 300 years, and the western-dominated global sociopolitical landscape est. 1776 (largely a product of American military superiority and foreign interventionalism) is now getting a little long in the tooth.
It's in their best interest to keep giving the masses their opiate.
The problem is that individuals often cannot see the bigger picture. It also does not necessarily follow that individuals benefit from aggregate wealth creation. If you are unemployed (by technology) and can no longer feed yourself or your dependents why do you really care that goods are now available cheaper and can be delivered 247: you still can't afford them. If in your lifetime technology only brought starvation upon you, why should you care that future generations will benefit. Last I checked, we are not indoctrinated from young to be altruistic martyrs for humanity nor do I recall that being a basic human instinct either.
So displacement is a somewhat inevitable outcome from mass technological disruption. It's very easy to champion progress when you're on the winning side, and ultimately progress is important. It falls to the powerful (the wealthy like Gates and Zuckerberg) and nation States to protect the interest of all citizens to make sure everyone's basic rights are still preserved. Especially over trasitory eras such as the current one.
I don't think we have enough examples from history to make this in some kind of universal law. Mass prosperity might just as well NOT be achieved.
The talks were filmed so they may be accessible somewhere, though I know the speaker writes on the subject so his writing may be more readily accessible.
As a free tip/shameless preach a book which has impacted me greatly recently is Ill Fares the Land by Tony Judt[1]. The more people that read this book, the better.
[0] http://conferences.oreilly.com/strata/hadoop-big-data-eu/pub...
[1]https://www.amazon.com/gp/aw/d/0143118765/ref=mp_s_a_1_1?ie=...
A link to the video of the talk is at: https://www.safaribooksonline.com/library/view/strata-hadoop...
If you'd like to read more on the topic, the book Big Data is at https://www.amazon.com/dp/B009N08NKW/ (or a synopsis, for free, is at https://www.foreignaffairs.com/articles/2013-04-03/rise-big-...)
Have stories to tell about how AI is changing business and society? Please reach me via twitter at @kncukier
Thanks!
We live in the real world so change doesn't happen overnight, but if truck driving becomes out-moded significantly faster than a truck driver could learn a new skill, then the displaced population will riot because they worked hard and did nothing wrong their whole lives and machines replaced them anyway.
And this is true for nearly all blue-collar and some white-collar workers, whose jobs would be threatened by advancements and automation made in their sector
[1] http://www.trucking.org/News_and_Information_Reports_Industr... (2010)
At least for part of it, in the US, almost half of spending is spent on welfare: social security and healthcare[0].
The problem is more nuanced than just "cutting defense" to make it 29% instead of 25%. I'm a pretty liberal guy, and I think a public option would eventually be cheaper in the long run than obamacare or what we had before, but I am under no delusion that simply throwing more money at the problem will fix it.
Academia requires more money, I agree. But what accounts for a quarter of spending already requires new ideas, not more money.
[0] https://en.wikipedia.org/wiki/United_States_federal_budget#/...
I see a pattern:
- Windows desktop monopoly -> MS makes billions while other software companies get crumbs
- FB social networking monopoly -> ad money collects to FB while regular businesses struggle to make advertising pay
- Apple store -> millions of app devs lose money while Apple becomes the most valuable company on back of their apps
- Recording labels have huge market share -> artists are poor and lose the rights to their own creations by signing unfair contracts
- Middle east oil money in the hands of a few arabs -> massive unrest in the region, state sponsored religion indoctrination, culminating in wars and terrorism
It so happens that accumulating massive wealth and power in the hands of a few leaves the rest of the population high an dry, frustrated and with lots of issues.
- Facebook employs thousands and thousands of people.
- Apple employs thousands and thousands of people.
- Record labels employ thousands and thousands of people.
- One of these things is not like the others.
Obviously those that do have do not want to distribute what they feel belongs to them, but this has been the case for forever. It's just a question of 'how much is too much'.
IMHO, Einstein had a great idea. While he's not known for his political beliefs, he did have them, and theorized a societal structure where the richest person could be up to, but not more than 10 times richer than the poorest person.
While it's obviously difficult to impossible to easily implement, I do believe that having a more evenly distributed society would solve most of humanity's violence problems, and maintaining some level of hierarchy based on merit/effort allows for healthy growth and positive incentives.
Rather than dream about the ideal world and not changing anything, we'd be much better off figuring out clever ways of financing more R&D, moonshots, etc. More X-Prizes, for example?
Privately funded challenges similar to the DARPA Challenges?
Or to put it a different way, if we put similar effort into genetic engineering we could have fire breathing dragons instead. Nobody has been to the moon in my lifetime (and I'm getting old!), and I have no hope of going (though probably someone will go in the next 10 years it won't be me). At least the circus could show me a dragon.
Without GPS, how practical would self driving cars be? Would the lack of GPS push self driving cars out another decade?
The OP said "lots of money was wasted". Sending rockets into space was very valuable. I don't think anyone questions that. But that was hardly the only part of the space race.
That is not actually the case. The Apollo Guidance Computer was one of the first (possibly the first) computers to use integrated circuits (RTL).
One of my professors in undergrad worked on it. They built the whole thing out of NOR gates, figuring that it would be better to have one component and test the crap out of it than have several different components. It's possible to think up arguments either way, but in any case, it worked. :-)
Of course, as long as you have either NAND or NOR (or either AND or OR and an inverter), it's possible to build any Boolean logic function.
An actual end to mass violence and cruelty would be infinitely more valuable than any of those things (except for clean energy).
People need to be more self sustained. We need technologies that will empower people and communities to rely on themselves and not depend on systems that are outside their control as much. I think that efficient agriculture in the hands of small communities, solar, 3d-printing, open sourced robotics and AI, open source and creative commons in general would help ease a lot of this tension. Violence comes from disenfranchisement and being socially marginalized, but if each community could stand on its own feet, this would be much less the case.
We need to reduce the gap between the super powerful and ordinary people to have a less polarized society, and I fear this will not happen through politics, but rather from technological empowerment. People are living today at a much higher standard than a century ago, and we have all seen the benefits of putting an internet enabled mobile phone in the hands of everyone - the things we could do today that we wouldn't have dreamed of 40 years ago... We just need to spread the benefits more evenly.
clean energy is infinitely more valuable than end to mass violence? That seems like a bit of an overstatement.
>We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in severe combined immunodeficient beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
So they load these little guys up with drug and use magnets to guide them into the tumor, which kind of works in SCID mice, although you'll note they make no claims about ability to actually kill or shrink tumors.
This news piece is awful, incidentally, but what else is new.
Yea, I think this is a little like calling a horse-drawn carriage an automobile.
1. It is hard to detect 2. Hypoxic tissue is hard to access as there is little blood supply 3. Hypoxic tissue is hard and physically robust
So according to this release, the work done here should help to address the issues of hypoxic tissue.
Is anyone with deeper subject knowledge able to discuss the viability of this research: how much is hype? Are there any risks or weaknesses to this method? How commercially viable is it to mass produce this?
I don't think anyone will be cured by this and it will no doubt cost an absolute fortune.
Here is a visualization of a small molecule binding to a protein (also a small one here, they often are much larger and incredibly complex - but predictablly so, since their chemical structure detemines how they fold): https://www.youtube.com/watch?v=g2Zj23pipuY
It's not a drug molecule but the exact same principle.
Here is an animation for a drug encapsulated in a nano shell: https://www.youtube.com/watch?v=emEua2eJp1U
The problem of normal drugs is that their shape and structure cannot be solely determined by the function they have to perform at the target. As a drug designer you have to design them that
a) They are delivered at all, which includes a lot of difficulties on its own, like oral drugs having to pass through the very active liver, or that it has to be hydrophilic to be transported in blood but hydrophobic to get through cell membranes into cells.
b) Since you cannot control where they end up they get everywhere, and they meet a zillion molecules on their way. If they bind anywhere else but in their target site, which is likely given that drugs are small molecules and the number of potential binding sites is huge, it's what you get to hear about as "side effects" of the drug.
So by putting the drug molecule into a container you now have the advantage that you separate transport and target selection from the drug action, and the drug designer can concentrate on the effect on the target without having to worry about how it gets there and undesirable interactions everywhere else.
The nano containers are still distributed throughout the whole body though, they just won't open at non-target sites.
Source: I took "Medicinal Chemistry: The Molecular Basis of Drug Discovery" when it was first offered on edX. I highly recommend it, the teacher, Prof. Erland Stevens, is great! Course: https://www.edx.org/course/medicinal-chemistry-molecular-bas...
https://www.reddit.com/r/Futurology/comments/4xz4nv/scientis...
Anybody know when/if this type of treatment could be used?
At the earliest a decade. Effectiveness of the treatment wasn't evaluated. Just the delivery mechanism. This things are kind of a toss up, because this isn't a drug per say, but a delivery method.It's pretty cutting edge tech. But if the right $$$ is behind it potentially see us in 5-10 years. But this would cost a load, and require a lot more researches be involved. This is before we even get to human trials.
Generally a drug/therapy isn't going to make it to market until the research teams spins off, or joins a bio-med startup. Then its 3-5 years away. Bio-med startups normally front the huge testing costs, then simply sell the patent+FDA approved drug to a large phrama firm for a HUGE pay off.